2 Days in Rome: How to Spend the Perfect 48 Hours in the City

Ciao, traveler! I’ve lived in Rome, and I know how to make the most of this incredible city—even in just 48 hours. This itinerary cuts the fluff and takes you straight to the must-sees, hidden gems, and best local eats. Walk in the footsteps of emperors, marvel at world-famous art, and navigate the city like a pro with my insider tips. Here’s how you can plan the perfect 2 days in Rome:

What to Do in Rome in 2 Days

Before we break it down hour by hour, here’s a quick look at what you’ll cover in your two days in Rome:

Day 1: Ancient Rome & The Historic Center

Morning: The Colosseum, Roman Forum, Palatine Hill

Afternoon: Piazza Venezia, Capitoline Hill, Piazza Navona

Evening: Pantheon, Trevi Fountain, Spanish Steps

Day 2: Vatican City & Baroque Rome

Morning: Vatican Museums, Sistine Chapel, St. Peter’s Basilica

Afternoon: Castel Sant’Angelo, Prati

Evening: Gianicolo Hill (for sunset), Dinner in Trastevere

Now, let’s dive into the details!

Day 1: Exploring Ancient Rome & The Historic Heart of the City

9:00 AM – The Colosseum

📍 Location: Piazza del Colosseo, 1
💰 Price: €16 (general entry), €22 (with Arena access)
⏳ Time Needed: 1.5 hours
🎟️ Booking: Must book online in advance. Check my guide here for visiting the Colosseum in 2025

Step right into history! The Colosseum isn’t just one of the most famous landmarks in the world—it’s an absolute must-see when in Rome. This ancient arena, once packed with 80,000 roaring spectators, saw epic gladiator battles, wild animal hunts, and grand spectacles designed to impress emperors and commoners alike. Walking through its towering arches, you can almost hear the echoes of the past. It’s a surreal experience, trust me!

Here are a few things to keep in mind. Arrive early to enjoy the morning light and beat the crowds—it makes all the difference. A guide (or an audio guide) is a must; the Colosseum is incredible, but the stories behind it bring it to life. And if you’re visiting in summer, brace yourself—it gets hot inside. Bring water, wear a hat, and don’t forget sunscreen. You’ll thank me later!

To get to the Colosseum, just get on Metro Line B and get off at Colosseo station. Once you step outside, you'll get an unmatched view of the Colosseum. For more information on how the public transportation works in Rome, check out my guide.

10:30 AM – Roman Forum & Palatine Hill

📍 Location: Via della Salara Vecchia, 5/6
💰 Price: Included in Colosseum ticket
⏳ Time Needed: 1.5 - 2 hours
🎟️ Booking: No additional ticket required

The Roman Forum was the beating heart of ancient Rome—think bustling markets, grand temples, and political drama straight out of a history book. Walking through these ruins, you’re literally stepping where emperors, senators, and everyday Romans once lived their daily lives. It’s mind-blowing to imagine!

And then there’s Palatine Hill—one of my absolute favorite spots in the city. According to legend, this is where Romulus founded Rome in 753 BC! Plus, the views from up here? Absolutely stunning! You get a breathtaking panorama of the Forum and beyond.

Here’s a pro tip—head up to the Palatine Terrace for an unreal view of the Forum. It’s the perfect spot for that postcard-worthy photo. To make the ruins feel even more alive, try a historical map app that shows reconstructions of what they once looked like—it adds a whole new layer to the experience. And most importantly, take your time. There’s so much history here, so don’t just breeze through—soak it all in!

12:30 PM – Lunch in Monti District

📍 Location: Rione Monti
💰 Price: €10-€20 per person
⏳ Time Needed: 1 hour

Monti is hands-down one of Rome’s most charming neighborhoods! Tucked away just a short stroll from the Colosseum, this area is a mix of old-world charm and modern cool—think cobblestone streets, ivy-covered buildings, and a perfect balance of authentic trattorias and trendy cafes. If you’re looking for a spot to refuel after a morning of sightseeing, this is it.

Where to Eat?

La Taverna dei Fori Imperiali – A family-run gem, famous for its homemade pasta and classic Roman dishes. Get the Cacio e Pepe—you won’t regret it!
Ai Tre Scalini – A cozy, historic wine bar with a great selection of local wines and delicious small plates. It’s got that laid-back, local vibe I love.

3:00 PM – Piazza Navona

📍 Location: Piazza Navona
💰 Price: Free
⏳ Time Needed: 30 minutes

Piazza Navona is one of the most stunning squares in Rome, and trust me, you’ll want to linger here. Picture elegant Baroque buildings, lively street artists, and the sound of fountains trickling as you sip your espresso—it’s pure Roman magic.

At the center of it all? Bernini’s Fountain of the Four Rivers, an absolute masterpiece featuring dramatic statues representing four great rivers from around the world. It’s got that theatrical flair that only Bernini could pull off!

If you love art, here’s a hidden gem—step inside Sant’Agnese in Agone, the stunning Baroque church overlooking the piazza. It’s often overlooked by tourists, so you’ll get to admire its breathtaking ceiling frescoes without the crowds. Trust me, it’s worth a peek!

And how to get to Piazza Navona from Monti? Easy! It’s just a 25-minute walk from Monti—a beautiful stroll through the historic center, passing by the iconic monument of Piazza Venezia.

4:00 PM – The Pantheon

📍 Location: Piazza della Rotonda
💰 Price: 5 Euros
⏳ Time Needed: 30 minutes
🎟️ Booking: Must book online in advance. Check out my guide to visiting the Pantheon in 2025 here.

The Pantheon isn’t just a must-see—it’s the best-preserved monument from Ancient Rome, and trust me, it’s absolutely jaw-dropping. Walk inside, look up, and boom—there’s that massive dome with its famous oculus, letting in a beam of light (or even rain if you’re lucky!). It’s pure architectural genius.

Oh, and history lovers? This place is also a resting place for legends like Raphael, one of the greatest artists of the Renaissance.

Getting to the Pantheon from Piazza Navona is super easy—it’s just a 5-minute walk. You’ll stroll through charming Roman streets, and suddenly, bam, the Pantheon appears in front of you like something out of a movie.

Pro Tip: If it starts raining while you’re at the Pantheon, don’t rush off—stick around! Watching the rain pour through the oculus and drain seamlessly inside is honestly one of the coolest things you’ll see in Rome. It’s like the building was designed for a little weather drama!

5:00 PM – Spanish Steps

📍 Location: Piazza di Spagna
💰 Price: Free
⏳ Time Needed: 30 minutes

The Spanish Steps are one of the most iconic spots in Rome, and trust me, they’re even more stunning in person. Climb to the top, and you’ll be rewarded with a gorgeous view of the city and the elegant Trinità dei Monti church watching over the square.

And let’s not forget—this area is shopping heaven! Right at the foot of the steps, you’ll find Via Condotti, lined with designer boutiques like Gucci, Prada, and Valentino. Even if you’re just window shopping, it’s a vibe.

From the Pantheon, the Spanish Steps are just a 10-minute walk away.

Heads up—sitting on the Spanish Steps is a no-go, so snap your pics and keep moving. But don’t rush off just yet! Grab an aperitivo at a cozy enoteca nearby and soak in the atmosphere. And if you love shopping, Via Condotti is right there, lined with Rome’s most luxurious boutiques—whether you're splurging or just window shopping, it’s worth a stroll! There are also plenty of restaurants around if you're in the mood for an early dinner.

7:00 PM – Trevi Fountain

📍 Location: Piazza di Trevi
💰 Price: Free
⏳ Time Needed: 30 minutes

If there’s one thing you absolutely must do in Rome, it’s tossing a coin into the Trevi Fountain! This stunning Baroque masterpiece is one of the most famous fountains in the world, and legend has it—throw a coin over your left shoulder, and you’re guaranteed to return to Rome. (I’ve done it, and well... I live here now!)

The fountain itself is a work of art—Neptune commanding the waters, dramatic sculptures, and the sound of cascading water make it feel almost magical.

The Trevi Fountain is just a 10-minute walk from the Spanish Steps.

My favorite time to visit the Trevi Fountain is late at night or early in the morning when the crowds have thinned out, and you can really take in the beauty of the place. But there’s something special about seeing it at night, all lit up—it feels almost magical. Just keep an eye on your belongings since it’s a busy spot. And before you leave, grab a gelato from Gelato di San Crispino nearby. Their honey flavor? Absolute perfection!

For more tips on visiting the Trevi Fountain in 2025, please check my full guide here.

Day 2: Vatican City & Baroque Rome

8:30 AM – Vatican Museums & Sistine Chapel

📍 Location: Viale Vaticano
💰 Price: €17 (general admission)
⏳ Time Needed: 2.5 - 3 hours
🎟️ Booking: Mandatory online in advance. Here is a tour I recommend.

Welcome to one of the most incredible art collections in the world! The Vatican Museums are packed with jaw-dropping masterpieces by Michelangelo, Raphael, and countless Renaissance legends. You could easily spend an entire day here, but the real showstopper? The Sistine Chapel.

The second you step inside, Michelangelo’s breathtaking ceiling frescoes will stop you in your tracks. Trust me, no photo does it justice. Just stand there, look up, and soak it all in.

To get to the Vatican Museums, just get on Metro Line A and get off at Ottaviano-S. Pietro station—from there, it’s a short walk to the entrance.

My Tips: If you're heading to the Sistine Chapel, try to arrive early—trust me, the crowds get intense, and you’ll want to enjoy the artwork without feeling like a sardine. Also, make sure to dress appropriately—shoulders and knees need to be covered since it's a religious site, and they’re pretty strict about it. And to really appreciate the history and symbolism, I recommend getting a guide or audio tour—it makes the whole experience 10 times better!

11:30 AM – St. Peter’s Basilica

📍 Location: Piazza San Pietro
💰 Price: Free (Dome climb: €8-€10)
⏳ Time Needed: 1.5 - 2 hours
🎟️ Booking: No booking needed, but expect long lines!

This isn’t just a church—it’s one of the most breathtaking, awe-inspiring places in the world. Designed by legends like Michelangelo and Bernini, St. Peter’s Basilica is packed with incredible artwork, including Michelangelo’s Pietà, which is so beautifully sculpted it looks almost alive.

But the real treat? The dome climb. If you’re up for it, you’ll get one of the best panoramic views in all of Rome. You can take an elevator halfway if you don’t want to tackle all the stairs, but either way, the view from the top is so worth it.

Getting to the Basilica is easy! It’s a quick 5-minute walk from the Vatican Museums exit—just follow the crowds heading toward the massive square.

1:00 PM – Lunch in PRATI

📍 Location: Prati District
💰 Price: €15-€25 per person
⏳ Time Needed: 1 hour

Prati is the perfect spot for a leisurely lunch in Rome. With its elegant boulevards, chic cafes, and stylish boutiques, this neighborhood offers a mix of modern flair and classic Roman charm. The food scene here is fantastic, with plenty of places to enjoy delicious local dishes. Take your time, relax over a long lunch, and soak in the sophisticated yet laid-back atmosphere—Prati is the ideal place to savor great food and enjoy the best of Rome.

Where to Eat?

Trattoria da Romolo Alla Mole Adriana: A local favorite for seafood lovers, this charming trattoria serves fresh, flavorful dishes that capture the essence of Roman seafood cuisine. Perfect for a relaxed meal with a view.

Sorbillo Prati: If you’re in the mood for some of the best pizza in Rome, Sorbillo is a must-visit. Known for its perfectly charred, Neapolitan-style pizza, this spot serves up fresh, high-quality ingredients that make every bite unforgettable. Whether you’re a pizza connoisseur or just craving a great meal, Sorbillo’s is the place to go.

2:30 PM – Castel Sant’Angelo

📍 Location: Lungotevere Castello, 50
💰 Price: €15
⏳ Time Needed: 1 hour
🎟️ Booking: Not necessary. But you could book a tour or skip-the-line tickets here.

This place has seen it all! Originally built as Emperor Hadrian’s mausoleum, Castel Sant’Angelo later became a fortress, a papal hideout, and even a prison (imagine being locked up in a place like this!). Today, it’s a museum packed with history, secret passageways, and—best of all—one of the most spectacular views over the Tiber River.

It’s also home to the Passetto di Borgo, a secret escape route that connects the castle to the Vatican. Popes used it to flee in times of danger—pretty cool, right?

It’s a scenic 10-minute walk from Prati, crossing the stunning Ponte Sant’Angelo, one of the prettiest bridges in Rome.

My Tips: If you're visiting Castel Sant'Angelo, make sure to take a break at the terrace café—having a coffee with that view? Absolutely priceless! While you're there, don't miss the secret passageway that links the castle to the Vatican—it’s like something straight out of a Dan Brown novel. And for the best photo ops, head up to the upper levels. You’ll get 360° views of Rome, and it’s way less crowded than other viewpoints in the city.

4:00 PM – Explore Trastevere

📍 Location: Trastevere District
💰 Price: Free
⏳ Time Needed: 1 hour

Trastevere is where Rome slows down and feels effortlessly cool. This neighborhood has a bohemian, almost village-like charm, with winding cobblestone streets, ivy-covered buildings, and piazzas buzzing with local life. It’s the perfect place to wander, get lost (in the best way), and just soak in the magic.

Make a stop at Piazza Santa Maria, the heart of Trastevere, and check out the stunning Santa Maria in Trastevere church—its golden mosaics are some of the most beautiful in the city.

From Castel Sant'Angelo, hop in a taxi and get to Trastevere within minutes. If not, you can also opt to get a bus. Check Moovit for routes and live bus timings.

My tips: If you’re in the mood for a peaceful escape, head to Orto Botanico, Rome’s hidden botanical gardens. It’s the perfect green retreat right in the heart of the city. For some amazing photo ops, check out Vicolo della Luce, one of Trastevere’s most picturesque alleyways—trust me, it’s straight-up postcard material. While you’re wandering around Trastevere, take the time to get lost in its charming, hidden alleys. They’re full of tiny, colorful streets that feel like a movie set. And if you’ve got extra time, make sure to stop by Santa Maria in Trastevere. It’s one of the oldest and most stunning churches in Rome, with golden mosaics inside that’ll take your breath away.

Sunset at Gianicolo Hill (optional)

📍 Location: Piazzale Giuseppe Garibaldi
💰 Price: Free
⏳ Time Needed: 30-45 minutes

If you’re looking for the best sunset views in Rome, Gianicolo Hill is the spot. It’s a local favorite, a little quieter than other viewpoints, and the panoramic skyline views are absolutely breathtaking. Watching the city glow in golden light as the sun sets behind St. Peter’s Basilica? Unreal.

It’s a scenic 15-minute uphill walk from Trastevere—a bit of a climb, but totally worth it! But you can also hop on the bus or get a taxi to bring you up to the terrace.

7:30 PM – Dinner in Trastevere

📍 Location: Trastevere District
💰 Price: €20-€40 per person
⏳ Time Needed: 1.5 - 2 hours

If there’s a perfect way to wrap up your Roman adventure, it’s with a long, delicious dinner in Trastevere. At night, this neighborhood comes alive—twinkling lights, lively piazzas, and the sound of clinking glasses as locals and travelers alike settle in for the night’s feast.

Where to Eat?

Trastevere is filled with a restaurants and bars, all serving traditional Roman dishes. Check out my full list of recommendations for where to eat in Trastevere here.

Conclusion: Arrivederci, Rome!

And just like that, your whirlwind 2 days in Rome comes to an end! In just 48 hours, you’ve stood inside the Colosseum, wandered through the ruins of the Roman Forum, marveled at the Vatican’s treasures, and enjoyed authentic Roman cuisine in Trastevere. Rome is a city that always leaves you wanting more—so don’t be surprised if you find yourself tossing another coin into the Trevi Fountain before you leave.

This 2 days in Rome itinerary ensures you make the most of your limited time, but remember—Rome wasn’t built in a day, and it certainly can’t be seen in just two. If you ever return (and trust me, you will!), there’s always more history, art, and delicious food waiting for you. Buon viaggio! 🇮🇹✨